Saturday, January 2, 2010

But what about splinters???


I'm intrigued by several reports that scientists have succeeded in transforming wood into bone, suitable for use in sheep at present, and hopefully to be used in humans in future. Discovery News reports:

A new procedure to turn blocks of wood into artificial bones has been developed by Italian scientists, who plan to implant them into large animals, and eventually humans.

Wood-derived bone substitute should allow live bones to heal faster and more securely after a break than currently available metal and ceramic implants.

The researchers chose wood because it closely resemble the physical structure of natural bone, "which is impossible to reproduce with conventional processing technology."

"Our purpose is to convert native wood structures into bioactive, inorganic compounds destined to substitute portions of bone," said Anna Tampieri, a scientist at the Instituto Di Scienza E Techologia Dei Materiali Ceramici in Italy.

To create the bone substitute, the scientists start with a block of wood -- red oak, rattan and sipo work best -- and heat it until all that remains is pure carbon, which is basically charcoal.

The scientists then spray calcium over the carbon, creating calcium carbide. Additional chemical and physical steps convert the calcium carbide into carbonated hydroxyapatite, which can then be implanted and serves as the artificial bone.

The entire process takes about one week and costs about $850 for a single block. One block translates to about one bone implant.

The researchers also note that they can create virtually any size or shape.

Wood-based implants would have several advantages over traditional titanium or ceramic implants, says Tampieri. Since their physical structure is more spongy than solid, like many metal or ceramic implants, live bone should grow into wood-derived bone substitute quicker and more securely.

. . .

However, wood-derived bone substitute are still not cleared for use in humans. The scientists are currently limited to sheep. Application in humans is likely years away, says Tampieri.

For now, however, wood-derived materials may be put to other use.

"Materials able to maintain adequate properties at extremely high temperatures and mechanical stress are highly sought after for use in several different applications, " said Tampieri. "Including, for example, catalytic silencers, space vehicles, turbine equipment for power generation plants and aircraft engines, like turbine blades, vanes, shrouds, and combustor components, and metal forming and glass blowing equipment."


There's more at the link.

The BBC has a video clip about the new discovery here. Interesting viewing.

It does, indeed, sound like a breakthrough . . . but what happens if the sheep (or person) in whom the wood-bone is implanted suffers another injury, one serious enough to fracture the wood-bone? Will it heal like normal bone, or will it require complex surgery to replace the entire component? And will splinters from the fractured wood-bone cause further internal injury, and/or be difficult to trace and remove?

Peter

3 comments:

  1. It sounds as though they've come up with a way to create a support framework within which natural bone can develop. The artificial structure is thereby eventually replaced and dissolved/absorbed, leaving the limb as good as new. Since the wood is basically turned into charcoal, there would be no wood fiber left; only the carbonized cellular structure would remain. It's pretty genius, really. I think there have been similar things done to generate soft tissues, although not using this wood technique. Very interesting reading!

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  2. It is interesting.. I think the various bone printing techniques that are being developed will win out in the end though*.

    This biotech revolution is just amazing - I keep thinking it's about time to look at changing fields. Talk about an age of miracles. :)




    * Not bone, but check out Organovo.

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