. . . here's evidence of how deadly it can be. Remember this when someone dismisses the round contemptuously as "Oh, that's only a .22!" It can still kill you.
I wrote a couple of years ago about '.22LR as a defensive round', pointing out that with proper training, it could be deadly efficient and effective. I've seen no reason to change my opinion of it since then - and I still have more firearms chambered for .22LR in my gun safe than for any other cartridge.